The city of Ann Arbor, Michigan, currently has 13 active clinical trials seeking participants for Depression research studies.
Sequential Multiple Assignment Randomized Trial for Bipolar Depression
Recruiting
This is a sequential multiple assignment randomized trial for adults (ages \> 18) with a bipolar disorder type 1 diagnosis currently experiencing a depressive episode. It is a randomized pragmatic trial that will compare four commonly prescribed treatments for bipolar depression, which includes three FDA-approved medications (Cariprazine, Quetiapine and Lurasidone) and one antipsychotic/antidepressant combination (Aripiprazole/Escitalopram).
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
05/21/2025
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Bipolar I Disorder, Depression
PCORI Comparative Effectiveness Study-Esketamine (Spravato) vs. Ketamine-Equivalence Study
Recruiting
The purpose of this study is to compare the relative effectiveness, acceptability, and side effects of ketamine delivered through an IV (a drip into the arm) which is not currently FDA approved for use in the treatment of treatment-resistant depression (TRD) and Esketamine (Spravato®), taken as a nasal spray which has received FDA approval for use in the treatment of treatment-resistant depression (TRD) in the treatment of patients with treatment-resistant depression (TRD). The study will look a... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/14/2025
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Depression
Family Acceptance Project Online (Pilot RCT)
Recruiting
Research shows that sexual and gender minority youth (SGMY) experience high rates of mental health problems and other challenges (e.g., social, academic). A major factor that leads to these challenges is family rejection (family behaviors and reactions that minimize, deny, ridicule and attempt to prevent or change a child's sexual orientation, gender identity and gender expression). Racial and ethnic minority youth experience the highest rates of family rejection and related health risks. The F... Read More
Gender:
ALL
Ages:
14 years and above
Trial Updated:
05/08/2025
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: LGBTQ, Racial Disparities, Family Relationships, Minority Stress, Depression, Anxiety, Drug Use, Teen Dating Violence, Sexual Risk Reduction
Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD
Recruiting
Efficacy, Safety, and Tolerability of two administrations of COMP360 in participants with treatment-resistant depression (TRD)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/08/2025
Locations: Michigan Clinical Research Institute PC, Ann Arbor, Michigan +1 locations
Conditions: Treatment Resistant Depression
Empower@Home: Community Implementation for Older Adults With Ambulatory Disabilities
Recruiting
This study is a randomized Type I hybrid effectiveness-implementation trial aimed at evaluating the effectiveness of Empower@Home, an internet-delivered cognitive-behavioral therapy (CBT) program supported by social service providers, in comparison to enhanced usual care for depression in older adults with ambulatory disabilities. A total of 64 participants with ambulatory disabilities will be randomly assigned to either the treatment group (Empower@Home) or the control group (enhanced usual car... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
05/07/2025
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Depression
The OBSERVE Protocol
Recruiting
This observational protocol is intended to provide long-term follow-up data on patients initiating or continuing treatment with either Spravato® or IV ketamine. This can provide us information on the patient acceptability and satisfaction, patterns of use, long-term effectiveness, and safety of the two approaches. This 5-year, 6-site study will enroll 450 total patients. The sites will comprise 3 academic medical centers and 3 community psychiatric practices.
Gender:
ALL
Ages:
All
Trial Updated:
05/02/2025
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Major Depression Disorder
A Wearable Morning Light Treatment for Postpartum Depression
Recruiting
This study will test a consumer health light therapy device (Re-Timer) for women with postpartum depression to better understand how it affects mood and the body clock (also called the circadian clock). Eligible participants will be enrolled and randomized after baseline assessments. In addition to using the Re-Timer light for 5 weeks participants will complete questionnaires at various timepoints, record sleep information, wear an actigraph watch, and provide saliva samples. Additionally, the... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
05/02/2025
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Post Partum Depression
Empower@Home: Hybrid Effectiveness-Implementation Randomized Controlled Trial (RCT)
Recruiting
This study is a randomized Type I hybrid effectiveness-implementation trial aimed at evaluating the effectiveness of Empower@Home, an internet-delivered cognitive-behavioral therapy (CBT) program supported by aging service providers, in comparison to enhanced usual care for homebound older adults with depressive symptoms. A total of 256 participants will be randomly assigned to either the treatment group (Empower@Home) or the control group (enhanced usual care) in a 1:1 allocation ratio, with ra... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
05/02/2025
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Depression
Michigan Men's Diabetes Project III(MenDIII): Mind and Motion
Recruiting
The Michigan Men's Diabetes Project III: Mind \& Motion is an 7-month pilot randomized clinical trial. The investigators are looking to recruit 80 Black men with type 2 diabetes (T2D) (need to have diagnosis for at least one year) that are over the age of 18. Participants also must be under the care of a physician for their diabetes, self report an Hemoglobin A1c (A1C) of 7.0% or more in the last year, be willing to participate in study events (weekly physical activity, exercise and Cognitive Be... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
03/19/2025
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Diabetes Mellitus, Type 2, Depressive Symptoms, Depression
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
Recruiting
Objectives of this study are to determine whether active VNS Therapy treatment is superior to a no stimulation control in producing a reduction in baseline depressive symptom severity, based on multiple depression scale assessment tools at 12 months from randomization.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/05/2024
Locations: Michigan Clinical Research Institute PC, Ann Arbor, Michigan
Conditions: Treatment Resistant Depression
Mood Lifters for Undergraduates
Recruiting
Large-scale, effective, low-cost, and evidence-based programs that can nimbly translate new research discoveries into prevention and care for psychosocial-based problems are urgently needed since the vast majority of people who need evidence-based care do not receive it. The purpose of this randomized control trial is to investigate the feasibility and efficacy of a Mood Lifters group template specifically for undergraduate students. Mood Lifters is an effective peer-led program that improves o... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/03/2024
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Depression, Anxiety, Mood Disorders, Mental Health Wellness 1, Stress
Academic-Community EPINET (AC-EPINET)
Recruiting
The investigators propose to examine the effects of CSC services delivered via TH (CSC-TH) versus the standard clinic-based CSC model (CSC-SD) on engagement and outcomes in a 12-month, randomized trial.
Gender:
ALL
Ages:
Between 16 years and 35 years
Trial Updated:
09/17/2024
Locations: Program for Risk Evaluation and Prevention (PREP) - University of Michigan, Ann Arbor, Michigan
Conditions: Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorders, Major Depression With Psychotic Features, Bipolar Disorder With Psychotic Features